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Cross-Working Group Activity Non-target Screening (NTS)



Co-ordinator: Eawag (Switzerland) 




In collaboration with EI, NIVA, NILU, UFZ 



Official starting date: September 2015



It is clear that the number of compounds measured today via target chemical analysis is not sufficient to provide an exhaustive overview of the quality status of our environment. The application of non-target screening techniques is needed to detect the presence of harmful substances (including degradation by-products and metabolites) beyond target approaches. 

NORMAN has a strong interest in promoting harmonisation of LC-HR-MS(MS) and GC-MS non-target-screening protocols, their application on different environmental matrices and their integration with biological monitoring tools. In connection with structure elucidation and pollution pattern recognition tools, this can facilitate the identification of possibly harmful compounds such as river basin specific pollutants (RBSPs). As non-target screening techniques are important for the prioritisation of chemicals (WG1), for the linkage between effects and chemical exposure (WG2 & WG3), as well as for the identification of emerging contaminants in the indoor environment (WG6) and through passive sampling, we have established NTS as a Cross-Working Group Activity. 

The activities of the NTS include:

-    Exchange and further development of smart non-target screening workflows from sample extraction through to analysis up to the final structure elucidation
-    Set-up and maintenance of the Suspect Lists Exchange and the NormaNEWS initiatives to support identification of “unknowns” 
-    Set-up of repositories for MS data (e.g. spectra in NORMAN Massbank) to support non-target screening
-    Designing, coordination and evaluation of Collaborative Trials on non-target screening: 2013/14 on water samples, 2015/16 on dust samples
-    Regular workshops aligned with other meetings to keep up-to-speed with developments.




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