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Collaborative Trial for Comprehensive examination of deconvolution and library search algorithms for non-target analysis

28 November 2018, Thessaloniki, Greece


Leader: NIVA, Norway (Activity organised as part of the CWG-NTS)

The differences in data-processing tools available in each laboratory are a significant source of observed variability in non-target screening exercises. The aim of this project is to organise an ILS to compare the performances of different deconvolution and library search algorithms commonly used for the non-target analysis of complex environmental samples. A well-characterised extract will be sent to each participant in the trial along with the instrumental methods for the analysis and data acquisition. Additionally, a list of features (i.e. retention time and m/z value pairs) will be sent to the participants for identification. The participants will be asked to run the samples in data independent mode. The participants will use their own vendor or open-source data processing tools for identification of those features. The final reports and the raw data will be submitted to the coordinators of the activity. The final results will go through a quality control step where the reported IDs will be compared to the actual identity of the features. A comprehensive guideline will be produced and disseminated within the network for confident non-target analysis using data-independent acquisition mode. A scientific paper will be produced.

The first meeting of the NORMAN experts to discuss the organisation of this interlaboratory study will take place on 28 November 2018 in Thessaloniki.

Deadline for registration: 1 November 2018